AirHint found the following cheapest return flights from Brussels (BRU) to Istanbul (IST) in December 2025 (see full year).

Return flights

05 Dec - 13 Dec	Pegasus Airlines	direct
05 Dec - 10 Dec	Pegasus Airlines	direct
07 Dec - 11 Dec	Ryanair
01 Dec - 08 Dec	Wizz Air Malta
01 Dec - 05 Dec	Wizz Air
01 Dec - 08 Dec	AJet	direct
01 Dec - 05 Dec	AJet	direct
03 Dec - 12 Dec	SunExpress
03 Dec - 12 Dec	AJet	direct
06 Dec - 14 Dec	AJet	direct
13 Dec - 02 Jan	Ryanair
29 Dec - 10 Jan	AJet
30 Dec - 08 Jan	Aegean Airlines
30 Dec - 06 Jan	SunExpress
30 Dec - 08 Jan	Turkish Airlines	direct
29 Dec - 10 Jan	Turkish Airlines	direct
19 Dec - 02 Jan	Air Serbia
17 Dec - 01 Jan	Wizz Air
21 Dec - 04 Jan	SKY express
21 Dec - 10 Jan	SKY express

Also check the deals for one-way flights from Brussels to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Brussels to Istanbul in December from $160

Return flights