AirHint found the following cheapest return flights from Brussels (BRU) to Santiago (SCL) in December 2025 (see full year).

Return flights

02 Dec - 24 Dec	Lufthansa
01 Dec - 15 Dec	Lufthansa
30 Dec - 23 Jan	Turkish Airlines
30 Dec - 24 Jan	Turkish Airlines
02 Dec - 06 Dec	Ryanair
11 Dec - 16 Jan	Ryanair
09 Dec - 16 Dec	Lufthansa
29 Dec - 21 Jan	Turkish Airlines
30 Dec - 15 Jan	TAP
24 Dec - 23 Jan	Ryanair
08 Dec - 13 Dec	Scandinavian Airlines
09 Dec - 15 Jan	Ryanair
30 Dec - 10 Jan	TAP
16 Dec - 22 Jan	Vueling Airlines
16 Dec - 23 Jan	Vueling Airlines
08 Dec - 14 Dec	Lufthansa
12 Dec - 26 Dec	Vueling Airlines
12 Dec - 14 Dec	Ryanair
13 Dec - 29 Dec	Ryanair
14 Dec - 28 Dec	Ryanair

Also check the deals for one-way flights from Brussels to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Brussels to Santiago in December from $912

Return flights