AirHint found the following cheapest return flights from Rome (CIA) to Istanbul (IST) in December 2025 (see full year).

Return flights

08 Dec - 15 Dec	Ryanair
09 Dec - 18 Dec	Ryanair
08 Dec - 18 Dec	Ryanair
11 Dec - 15 Dec	Ryanair
11 Dec - 16 Dec	Ryanair
13 Dec - 16 Dec	Ryanair
13 Dec - 15 Dec	Ryanair
11 Dec - 18 Dec	Ryanair
12 Dec - 16 Dec	Ryanair
10 Dec - 16 Dec	Ryanair
03 Dec - 17 Jan	Ryanair
18 Dec - 24 Jan	Ryanair
02 Dec - 01 Jan	Ryanair
17 Dec - 10 Jan	Ryanair
06 Dec - 11 Jan	Ryanair
22 Dec - 08 Jan	Ryanair
18 Dec - 09 Jan	Ryanair
31 Dec - 09 Jan	Ryanair
12 Dec - 07 Jan	Ryanair
22 Dec - 01 Jan	Ryanair

Also check the deals for one-way flights from Rome to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Istanbul in December from $159

Return flights