AirHint found the following cheapest return flights from Rome (CIA) to Istanbul (IST) in April 2026 (see full year).

Return flights

30 Apr - 03 May	Ryanair
01 Apr - 15 Apr	Ryanair
01 Apr - 03 Apr	Ryanair
09 Apr - 11 Apr	Ryanair
01 Apr - 07 Apr	Ryanair
02 Apr - 07 Apr	Ryanair
01 Apr - 05 Apr	Ryanair
13 Apr - 21 Apr	Ryanair
02 Apr - 05 Apr	Ryanair
02 Apr - 06 Apr	Ryanair
23 Apr - 30 Apr	Ryanair
24 Apr - 01 May	Ryanair
25 Apr - 06 May	Ryanair
30 Apr - 05 May	Ryanair
25 Apr - 05 May	Ryanair
29 Apr - 03 May	Ryanair
29 Apr - 05 May	Ryanair
24 Apr - 02 May	Ryanair
25 Apr - 03 May	Ryanair

Also check the deals for one-way flights from Rome to Istanbul in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Istanbul in April from $223

Return flights