AirHint found the following cheapest return flights from Rome (CIA) to Istanbul (IST) in May 2026 (see full year).

Return flights

14 May - 17 May	Ryanair
07 May - 12 May	Ryanair
12 May - 19 May	Ryanair
13 May - 18 May	Ryanair
09 May - 16 May	Ryanair
04 May - 12 May	Ryanair
09 May - 23 May	Ryanair
19 May - 20 May	Ryanair
01 May - 06 May	Ryanair
01 May - 07 May	Ryanair
29 May - 02 Jun	Ryanair
29 May - 03 Jun	Ryanair
28 May - 01 Jun	Ryanair
30 May - 02 Jun	Ryanair
30 May - 03 Jun	Ryanair
28 May - 02 Jun	Ryanair
30 May - 04 Jun	Ryanair
28 May - 04 Jun	Ryanair
29 May - 01 Jun	Ryanair

Also check the deals for one-way flights from Rome to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Istanbul in May from $233

Return flights