AirHint found the following cheapest return flights from Rome (CIA) to Istanbul (IST) in September 2026 (see full year).

Return flights

25 Sep - 29 Sep	Ryanair
22 Sep - 29 Sep	Ryanair
16 Sep - 22 Sep	Ryanair
24 Sep - 15 Oct	Ryanair
23 Sep - 29 Sep	Ryanair
18 Sep - 22 Sep	Ryanair
10 Sep - 14 Sep	Ryanair
30 Sep - 04 Oct	Ryanair
15 Sep - 22 Sep	Ryanair
10 Sep - 18 Sep	Ryanair
29 Sep - 04 Oct	Ryanair
22 Sep - 06 Oct	Ryanair
22 Sep - 26 Sep	Ryanair
16 Sep - 19 Sep	Ryanair
26 Sep - 03 Oct	Ryanair
29 Sep - 07 Oct	Ryanair
08 Sep - 06 Oct	Ryanair
26 Sep - 07 Oct	Ryanair
16 Sep - 02 Oct	Ryanair

Also check the deals for one-way flights from Rome to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Istanbul in September from $179

Return flights