AirHint found the following cheapest return flights from Charlotte (CLT) to Madrid (MAD) in October 2025 (see full year).

Return flights

29 Oct - 12 Nov	Spirit Airlines
29 Oct - 22 Nov	Spirit Airlines
22 Oct - 15 Nov	Spirit Airlines
22 Oct - 29 Oct	Air Canada
26 Oct - 15 Nov	Spirit Airlines
22 Oct - 15 Nov	Iberia	direct
26 Oct - 15 Nov	Iberia	direct
20 Oct - 15 Nov	Iberia	direct
29 Oct - 22 Nov	Finnair	direct
19 Oct - 24 Oct	Spirit Airlines
19 Oct - 23 Oct	Frontier Airlines
19 Oct - 25 Oct	Air Canada
19 Oct - 24 Oct	Finnair	direct
19 Oct - 23 Oct	British Airways	direct
19 Oct - 25 Oct	British Airways	direct

Also check the deals for one-way flights from Charlotte to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Charlotte to Madrid in October from $618

Return flights