AirHint found the following cheapest return flights from Columbus (CMH) to Rome (FCO) in October 2025 (see full year).

Return flights

18 Oct - 15 Nov	Spirit Airlines
18 Oct - 04 Nov	Spirit Airlines
28 Oct - 10 Nov	Spirit Airlines
18 Oct - 10 Nov	Spirit Airlines
28 Oct - 03 Nov	Spirit Airlines
18 Oct - 28 Oct	Spirit Airlines
30 Oct - 06 Nov	United
15 Oct - 22 Oct	United
20 Oct - 27 Oct	United
25 Oct - 01 Nov	United
10 Oct - 17 Oct	United
10 Oct - 18 Oct	Allegiant Air
05 Oct - 12 Oct	United

Also check the deals for one-way flights from Columbus to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Columbus to Rome in October from $445

Return flights