AirHint found the following cheapest return flights from Columbus (CMH) to Rome (FCO) in September 2025 (see full year).

Return flights

16 Sep - 24 Sep	Spirit Airlines
03 Sep - 08 Sep	Spirit Airlines
02 Sep - 09 Sep	United
17 Sep - 24 Sep	United
23 Sep - 30 Sep	United
08 Sep - 15 Sep	United
11 Sep - 18 Sep	United
14 Sep - 21 Sep	United
29 Sep - 06 Oct	United
05 Sep - 12 Sep	United
20 Sep - 27 Sep	United
25 Sep - 09 Oct	Allegiant Air
26 Sep - 03 Oct	United

Also check the deals for one-way flights from Columbus to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Columbus to Rome in September from $511

Return flights