AirHint found the following cheapest return flights from Cape Town (CPT) to Istanbul (IST) in September 2025 (see full year).

Return flights

10 Sep - 17 Sep	KLM
14 Sep - 22 Sep	KLM
01 Sep - 07 Sep	Ethiopian Airlines
03 Sep - 11 Sep	KLM
17 Sep - 24 Sep	Qatar Airways
04 Sep - 14 Sep	KLM
03 Sep - 13 Sep	KLM
12 Sep - 19 Sep	KLM
02 Sep - 17 Sep	KLM
01 Sep - 20 Sep	KLM
01 Sep - 01 Oct	KLM
23 Sep - 07 Oct	Emirates
23 Sep - 05 Oct	FlySafair
24 Sep - 05 Oct	Emirates
27 Sep - 05 Oct	FlySafair
26 Sep - 04 Oct	FlySafair
08 Sep - 08 Oct	KLM
29 Sep - 10 Oct	Qatar Airways
23 Sep - 07 Oct	Turkish Airlines	direct
02 Sep - 02 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Cape Town to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cape Town to Istanbul in September from $646

Return flights