AirHint found the following cheapest return flights from Cartagena (CTG) to Madrid (MAD) in September 2025 (see full year).

Return flights

20 Sep - 28 Sep	KLM
30 Sep - 08 Oct	Avianca
30 Sep - 07 Oct	Avianca
30 Sep - 21 Oct	Avianca
30 Sep - 20 Oct	Avianca
30 Sep - 18 Oct	Avianca
25 Sep - 01 Oct	Spirit Airlines
26 Sep - 16 Oct	Spirit Airlines
21 Sep - 29 Sep	Avianca
20 Sep - 27 Sep	JetSmart
22 Sep - 29 Sep	Avianca
25 Sep - 02 Oct	Spirit Airlines
24 Sep - 29 Sep	Spirit Airlines
24 Sep - 20 Oct	LATAM Airlines Group
28 Sep - 05 Oct	Arajet
22 Sep - 30 Sep	Avianca
20 Sep - 29 Sep	JetSmart
23 Sep - 30 Sep	Avianca
22 Sep - 28 Sep	Avianca
20 Sep - 30 Sep	JetSmart

Also check the deals for one-way flights from Cartagena to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cartagena to Madrid in September from $876

Return flights