AirHint found the following cheapest return flights from Cartagena (CTG) to Madrid (MAD) in September 2025 (see full year).

Return flights

18 Sep - 28 Sep	Spirit Airlines
08 Sep - 15 Sep	Spirit Airlines
03 Sep - 10 Sep	Spirit Airlines
18 Sep - 27 Sep	Spirit Airlines
19 Sep - 01 Oct	JetSmart
06 Sep - 16 Sep	KLM
06 Sep - 19 Sep	KLM
24 Sep - 20 Oct	Plus Ultra Lineas Aereas
22 Sep - 04 Oct	Plus Ultra Lineas Aereas
18 Sep - 04 Oct	Plus Ultra Lineas Aereas
18 Sep - 25 Sep	Plus Ultra Lineas Aereas
04 Sep - 11 Sep	Spirit Airlines
23 Sep - 23 Oct	KLM
06 Sep - 15 Sep	KLM
18 Sep - 28 Oct	KLM
29 Sep - 28 Oct	KLM
30 Sep - 28 Oct	KLM
12 Sep - 19 Sep	Avianca
17 Sep - 06 Oct	Plus Ultra Lineas Aereas
17 Sep - 04 Oct	Plus Ultra Lineas Aereas

Also check the deals for one-way flights from Cartagena to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cartagena to Madrid in September from $681

Return flights