AirHint found the following cheapest return flights from Cancun (CUN) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

01 Oct - 08 Oct	Avianca	direct
01 Oct - 15 Oct	Avianca	direct
16 Oct - 19 Oct	Avianca	direct
05 Oct - 26 Oct	Copa
04 Oct - 11 Oct	Copa
17 Oct - 26 Oct	Copa
15 Oct - 19 Oct	Copa
29 Oct - 03 Nov	Copa
03 Oct - 06 Oct	Aeromexico
10 Oct - 15 Oct	Copa
09 Oct - 13 Oct	Copa
31 Oct - 03 Nov	Copa
31 Oct - 03 Nov	Avianca	direct
27 Oct - 01 Nov	Avianca	direct
29 Oct - 03 Nov	Avianca	direct

Also check the deals for one-way flights from Cancun to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cancun to Rio Negro in October from $302

Return flights