AirHint found the following cheapest return flights from Cancun (CUN) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

16 Oct - 20 Oct	Copa
24 Oct - 26 Oct	Copa
07 Oct - 14 Oct	Copa
30 Oct - 08 Nov	Copa
16 Oct - 23 Oct	Copa
20 Oct - 24 Oct	Copa
06 Oct - 29 Oct	Copa
21 Oct - 28 Oct	Copa
30 Oct - 04 Nov	Copa
03 Oct - 12 Oct	Copa
24 Oct - 24 Oct	Copa
21 Oct - 24 Oct	Copa
30 Oct - 09 Nov	Copa
30 Oct - 03 Nov	Copa
26 Oct - 10 Nov	Viva
26 Oct - 04 Nov	Viva
26 Oct - 08 Nov	Viva
26 Oct - 09 Nov	Viva
31 Oct - 10 Nov	Viva
31 Oct - 04 Nov	Viva

Also check the deals for one-way flights from Cancun to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cancun to Rio Negro in October from $277

Return flights