AirHint found the following cheapest return flights from Cancun (CUN) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

25 Sep - 28 Sep	Copa
28 Sep - 29 Sep	Copa
27 Sep - 01 Oct	Copa
26 Sep - 29 Sep	Copa
24 Sep - 01 Oct	Copa
16 Sep - 23 Sep	Copa
17 Sep - 24 Sep	Avianca	direct
18 Sep - 24 Sep	Copa
25 Sep - 11 Oct	Viva
19 Sep - 20 Sep	Viva
27 Sep - 11 Oct	Viva
16 Sep - 30 Sep	Copa
18 Sep - 25 Sep	Copa
27 Sep - 18 Oct	Viva
19 Sep - 22 Sep	Viva
28 Sep - 11 Oct	Viva
29 Sep - 11 Oct	Viva
28 Sep - 18 Oct	Viva
29 Sep - 18 Oct	Viva
20 Sep - 11 Oct	Viva

Also check the deals for one-way flights from Cancun to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cancun to Rio Negro in September from $278

Return flights