AirHint found the following cheapest return flights from Cuzco (CUZ) to Santiago (SCL) in October 2025 (see full year).

Return flights

28 Oct - 04 Nov	JetSmart
31 Oct - 04 Nov	JetSmart
14 Oct - 04 Nov	JetSmart
21 Oct - 04 Nov	JetSmart
25 Oct - 04 Nov	JetSmart
28 Oct - 16 Nov	JetSmart
28 Oct - 08 Nov	JetSmart
31 Oct - 16 Nov	JetSmart
31 Oct - 08 Nov	JetSmart
28 Oct - 05 Nov	JetSmart
14 Oct - 21 Oct	JetSmart
14 Oct - 19 Oct	JetSmart
14 Oct - 28 Oct	JetSmart
28 Oct - 31 Oct	JetSmart
14 Oct - 31 Oct	JetSmart
14 Oct - 24 Oct	JetSmart
28 Oct - 30 Oct	JetSmart
14 Oct - 30 Oct	JetSmart
14 Oct - 17 Oct	JetSmart
08 Oct - 11 Oct	JetSmart

Also check the deals for one-way flights from Cuzco to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cuzco to Santiago in October from $202

Return flights