AirHint found the following cheapest return flights from Cuzco (CUZ) to Santiago (SCL) in December 2025 (see full year).

Return flights

13 Dec - 25 Dec	JetSmart
08 Dec - 25 Dec	JetSmart
03 Dec - 09 Dec	JetSmart
03 Dec - 05 Dec	JetSmart
03 Dec - 04 Dec	JetSmart
16 Dec - 25 Dec	JetSmart
05 Dec - 25 Dec	JetSmart
31 Dec - 16 Jan	JetSmart
31 Dec - 07 Jan	JetSmart
31 Dec - 04 Jan	JetSmart
31 Dec - 15 Jan	JetSmart
31 Dec - 05 Jan	JetSmart
31 Dec - 17 Jan	JetSmart
01 Dec - 09 Dec	JetSmart
01 Dec - 05 Dec	JetSmart
05 Dec - 09 Dec	JetSmart
16 Dec - 05 Jan	JetSmart
16 Dec - 04 Jan	JetSmart
31 Dec - 06 Jan	JetSmart
19 Dec - 07 Jan	JetSmart

Also check the deals for one-way flights from Cuzco to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Cuzco to Santiago in December from $231

Return flights