AirHint found the following cheapest return flights from Cuzco (CUZ) to Santiago (SCL) in September 2025 (see full year).

Return flights

30 Sep - 21 Oct	JetSmart
30 Sep - 08 Oct	JetSmart
30 Sep - 12 Oct	JetSmart
30 Sep - 07 Oct	JetSmart
30 Sep - 15 Oct	JetSmart
30 Sep - 02 Oct	JetSmart
30 Sep - 20 Oct	JetSmart
30 Sep - 13 Oct	JetSmart
17 Sep - 23 Sep	JetSmart
17 Sep - 28 Sep	JetSmart
17 Sep - 01 Oct	JetSmart
05 Sep - 07 Sep	Sky Airline
06 Sep - 23 Sep	JetSmart
17 Sep - 08 Oct	JetSmart
17 Sep - 22 Sep	JetSmart
15 Sep - 23 Sep	JetSmart
15 Sep - 28 Sep	JetSmart
06 Sep - 22 Sep	JetSmart
15 Sep - 22 Sep	JetSmart
10 Sep - 23 Sep	JetSmart

Also check the deals for one-way flights from Cuzco to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cuzco to Santiago in September from $232

Return flights