AirHint found the following cheapest return flights from Denver (DEN) to Prague (PRG) in October 2025 (see full year).

Return flights

21 Oct - 04 Nov	Icelandair
15 Oct - 22 Oct	Frontier Airlines
02 Oct - 16 Oct	Frontier Airlines
12 Oct - 22 Oct	Turkish Airlines
07 Oct - 20 Oct	Frontier Airlines
24 Oct - 07 Nov	Turkish Airlines
01 Oct - 06 Oct	Frontier Airlines
10 Oct - 17 Oct	Air Canada
13 Oct - 19 Oct	British Airways
11 Oct - 18 Oct	Frontier Airlines
10 Oct - 18 Oct	WestJet
17 Oct - 30 Oct	Delta

Also check the deals for one-way flights from Denver to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Denver to Prague in October from $569

Return flights