AirHint found the following cheapest return flights from Des Moines (DSM) to Prague (PRG) in October 2025 (see full year).
Return flights
| 06 Oct - 13 Oct | Allegiant Air | ||
| 13 Oct - 20 Oct | Delta | ||
| 12 Oct - 19 Oct | Lufthansa |
Also check the deals for one-way flights from Des Moines to Prague in October.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
Find us on social media