AirHint found the following cheapest return flights from Detroit (DTW) to Istanbul (IST) in September 2025 (see full year).

Return flights

04 Sep - 08 Sep	Spirit Airlines
22 Sep - 29 Sep	Spirit Airlines
04 Sep - 13 Sep	Spirit Airlines
22 Sep - 29 Sep	Turkish Airlines	direct
15 Sep - 30 Sep	Air Canada
04 Sep - 08 Sep	Turkish Airlines	direct
28 Sep - 05 Oct	Spirit Airlines
28 Sep - 05 Oct	Turkish Airlines	direct
04 Sep - 13 Sep	Turkish Airlines	direct

Also check the deals for one-way flights from Detroit to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Istanbul in September from $541

Return flights