AirHint found the following cheapest return flights from Detroit (DTW) to Prague (PRG) in October 2025 (see full year).

Return flights

18 Oct - 01 Nov	Icelandair
25 Oct - 01 Nov	Icelandair
14 Oct - 21 Oct	Spirit Airlines
28 Oct - 11 Nov	Lufthansa
29 Oct - 12 Nov	Lufthansa
29 Oct - 05 Nov	Spirit Airlines
21 Oct - 28 Oct	Turkish Airlines
22 Oct - 29 Oct	Lufthansa
14 Oct - 28 Oct	Spirit Airlines
20 Oct - 27 Oct	Lufthansa
23 Oct - 28 Oct	Turkish Airlines
24 Oct - 01 Nov	Scandinavian Airlines
23 Oct - 31 Oct	Turkish Airlines
04 Oct - 07 Oct	Spirit Airlines
23 Oct - 29 Oct	Spirit Airlines
10 Oct - 14 Oct	Frontier Airlines

Also check the deals for one-way flights from Detroit to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Prague in October from $439

Return flights