AirHint found the following cheapest return flights from Detroit (DTW) to Panama City (PTY) in April 2026 (see full year).
Return flights
| 11 Apr - 15 Apr | Spirit Airlines | ||
| 20 Apr - 01 May | Frontier Airlines | ||
| 06 Apr - 12 Apr | Spirit Airlines | ||
| 03 Apr - 05 Apr | Spirit Airlines | ||
| 05 Apr - 12 Apr | Copa |
Also check the deals for one-way flights from Detroit to Panama City in April.
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