AirHint found the following cheapest return flights from Duesseldorf (DUS) to Prague (PRG) in October 2025 (see full year).

Return flights

09 Oct - 16 Oct	Ryanair
09 Oct - 10 Oct	Ryanair
25 Oct - 30 Oct	Eurowings	direct
06 Oct - 10 Oct	Ryanair
25 Oct - 31 Oct	easyJet
07 Oct - 10 Oct	Ryanair
07 Oct - 09 Oct	Ryanair
19 Oct - 22 Oct	Eurowings	direct
28 Oct - 31 Oct	Eurowings	direct
09 Oct - 14 Oct	Eurowings	direct
27 Oct - 01 Nov	easyJet
30 Oct - 04 Nov	easyJet
31 Oct - 05 Nov	easyJet
30 Oct - 04 Nov	Eurowings	direct
31 Oct - 02 Nov	Lufthansa
28 Oct - 02 Nov	Eurowings
31 Oct - 05 Nov	Eurowings	direct
28 Oct - 02 Nov	Eurowings	direct
31 Oct - 02 Nov	Eurowings	direct

Also check the deals for one-way flights from Duesseldorf to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Duesseldorf to Prague in October from $133

Return flights