AirHint found the following cheapest return flights from Duesseldorf (DUS) to Prague (PRG) in September 2025 (see full year).

Return flights

29 Sep - 01 Oct	Eurowings	direct
14 Sep - 18 Sep	Eurowings
30 Sep - 01 Oct	Eurowings	direct
30 Sep - 02 Oct	Eurowings	direct
14 Sep - 18 Sep	Eurowings	direct
14 Sep - 15 Sep	Eurowings
14 Sep - 19 Sep	Eurowings
23 Sep - 24 Sep	easyJet
23 Sep - 26 Sep	easyJet
21 Sep - 25 Sep	Eurowings
24 Sep - 26 Sep	easyJet
21 Sep - 26 Sep	Eurowings
29 Sep - 30 Sep	Eurowings	direct
29 Sep - 06 Oct	Eurowings
25 Sep - 02 Oct	easyJet
28 Sep - 03 Oct	Eurowings
30 Sep - 03 Oct	Ryanair
28 Sep - 04 Oct	Eurowings	direct
29 Sep - 05 Oct	Eurowings	direct
25 Sep - 02 Oct	Eurowings	direct

Also check the deals for one-way flights from Duesseldorf to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Duesseldorf to Prague in September from $139

Return flights