AirHint found the following cheapest return flights from Newark (EWR) to Panama City (PTY) in October 2025 (see full year).

Return flights

23 Oct - 27 Oct	Spirit Airlines
05 Oct - 17 Oct	Spirit Airlines
23 Oct - 26 Oct	Spirit Airlines
25 Oct - 29 Oct	Spirit Airlines
04 Oct - 08 Oct	Spirit Airlines
25 Oct - 01 Nov	Spirit Airlines
06 Oct - 16 Oct	Spirit Airlines
16 Oct - 22 Oct	Spirit Airlines
28 Oct - 02 Nov	Spirit Airlines
03 Oct - 06 Oct	Spirit Airlines
09 Oct - 13 Oct	Volaris El Salvador
06 Oct - 13 Oct	Spirit Airlines
25 Oct - 01 Nov	United	direct
28 Oct - 02 Nov	United	direct
31 Oct - 08 Nov	Copa	direct

Also check the deals for one-way flights from Newark to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Newark to Panama City in October from $380

Return flights