Cheapest return flights from Rome to Istanbul in May from $269

AirHint found the following cheapest return flights from Rome (FCO) to Istanbul (IST) in May 2026 (see full year).

Return flights

09 May - 12 May Lufthansa
20 May - 21 May Turkish Airlines direct
08 May - 11 May Turkish Airlines direct
12 May - 26 May Turkish Airlines direct
09 May - 12 May Turkish Airlines direct
19 May - 21 May Turkish Airlines direct
18 May - 21 May Turkish Airlines direct
20 May - 22 May Turkish Airlines direct
18 May - 22 May Turkish Airlines direct
18 May - 24 May Turkish Airlines direct
30 May - 06 Jun Turkish Airlines direct

Also check the deals for one-way flights from Rome to Istanbul in May.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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