AirHint found the following cheapest return flights from Rome (FCO) to Panama City (PTY) in December 2025 (see full year).

Return flights

06 Dec - 16 Dec	Air France
06 Dec - 23 Dec	Air Europa
24 Dec - 31 Dec	Air Europa
13 Dec - 07 Jan	Turkish Airlines
24 Dec - 07 Jan	Iberia
18 Dec - 16 Jan	Air Europa
18 Dec - 26 Dec	Air Europa
20 Dec - 27 Dec	Turkish Airlines
28 Dec - 07 Jan	Vueling Airlines
17 Dec - 06 Jan	Turkish Airlines
19 Dec - 28 Dec	Air Europa
20 Dec - 16 Jan	Air Europa
29 Dec - 06 Jan	KLM
22 Dec - 07 Jan	Turkish Airlines
12 Dec - 04 Jan	Turkish Airlines
27 Dec - 06 Jan	Air France

Also check the deals for one-way flights from Rome to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Panama City in December from 1295CAD

Return flights