AirHint found the following cheapest return flights from Rome (FCO) to Santiago (SCL) in October 2025 (see full year).

Return flights

09 Oct - 22 Oct	Delta
07 Oct - 22 Oct	Delta
07 Oct - 13 Nov	Delta
06 Oct - 13 Nov	Delta
07 Oct - 12 Nov	Delta
07 Oct - 05 Nov	Delta
07 Oct - 06 Nov	Delta
07 Oct - 24 Nov	Delta
09 Oct - 19 Oct	Delta
02 Oct - 13 Nov	easyJet
02 Oct - 05 Nov	easyJet
28 Oct - 23 Nov	Delta
23 Oct - 08 Nov	Delta
02 Oct - 05 Oct	Ryanair
15 Oct - 26 Oct	TAP
19 Oct - 26 Oct	Aeroitalia
10 Oct - 13 Oct	Norse Atlantic Airways
03 Oct - 18 Oct	Wizz Air Malta
05 Oct - 10 Oct	Ryanair
19 Oct - 31 Oct	Aeroitalia

Also check the deals for one-way flights from Rome to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in October from $841

Return flights