AirHint found the following cheapest return flights from Frankfurt (FRA) to Panama City (PTY) in October 2025 (see full year).

Return flights

25 Oct - 08 Nov	Air Europa
09 Oct - 23 Oct	Air France
08 Oct - 20 Oct	Condor	direct
22 Oct - 09 Nov	Air Europa
22 Oct - 05 Nov	Air Europa
29 Oct - 17 Nov	Air Europa
31 Oct - 23 Nov	Air Europa
24 Oct - 09 Nov	Air Europa
05 Oct - 20 Oct	Condor	direct
13 Oct - 05 Nov	Air Europa
05 Oct - 16 Oct	Condor	direct
22 Oct - 23 Oct	Condor	direct
31 Oct - 14 Nov	Air Europa
24 Oct - 07 Nov	Air Europa
01 Oct - 22 Oct	Brussels Airlines
04 Oct - 17 Oct	Air France
11 Oct - 24 Oct	Air France
03 Oct - 18 Oct	United
01 Oct - 10 Oct	United
29 Oct - 17 Nov	Condor	direct

Also check the deals for one-way flights from Frankfurt to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Panama City in October from $659

Return flights