AirHint found the following cheapest return flights from Frankfurt (FRA) to Panama City (PTY) in September 2025 (see full year).

Return flights

17 Sep - 29 Sep	Condor	direct
24 Sep - 09 Oct	Condor	direct
09 Sep - 23 Sep	Air Europa
13 Sep - 11 Oct	KLM
24 Sep - 13 Oct	KLM
06 Sep - 06 Oct	KLM
01 Sep - 10 Sep	United
24 Sep - 13 Oct	Condor	direct
13 Sep - 27 Sep	Air Europa
13 Sep - 04 Oct	Air Europa
21 Sep - 10 Oct	KLM
13 Sep - 03 Oct	KLM
03 Sep - 27 Sep	Air Europa
03 Sep - 28 Sep	Air Europa
03 Sep - 18 Sep	Condor	direct
14 Sep - 02 Oct	Condor	direct
06 Sep - 19 Sep	Air Europa
07 Sep - 15 Sep	Condor	direct
14 Sep - 22 Sep	Air France
01 Sep - 15 Oct	United

Also check the deals for one-way flights from Frankfurt to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Panama City in September from $657

Return flights