AirHint found the following cheapest return flights from Frankfurt (FRA) to Santiago (SCL) in October 2025 (see full year).

Return flights

27 Oct - 22 Nov	Air Canada
28 Oct - 27 Nov	Air Canada
27 Oct - 10 Nov	Air Canada
29 Oct - 12 Nov	Air Canada
27 Oct - 13 Nov	Air Canada
26 Oct - 02 Nov	Delta
23 Oct - 08 Nov	Delta
09 Oct - 19 Oct	Delta
09 Oct - 23 Oct	Delta
22 Oct - 11 Nov	Delta
02 Oct - 23 Oct	Delta
02 Oct - 16 Oct	Delta
02 Oct - 21 Oct	Delta
09 Oct - 16 Oct	Delta
09 Oct - 30 Oct	Delta
24 Oct - 29 Oct	Delta
25 Oct - 29 Oct	Delta
19 Oct - 26 Oct	Delta
12 Oct - 03 Nov	Condor
22 Oct - 30 Nov	Delta

Also check the deals for one-way flights from Frankfurt to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Santiago in October from $901

Return flights