AirHint found the following cheapest return flights from Frankfurt (FRA) to Santiago (SCL) in September 2025 (see full year).

Return flights

09 Sep - 16 Sep	Delta
15 Sep - 28 Sep	Delta
07 Sep - 22 Sep	Delta
08 Sep - 21 Sep	Delta
08 Sep - 23 Sep	Delta
07 Sep - 24 Sep	Delta
09 Sep - 26 Sep	Delta
08 Sep - 24 Sep	Delta
09 Sep - 23 Sep	Delta
07 Sep - 23 Sep	Delta
14 Sep - 09 Oct	Delta
08 Sep - 08 Oct	Delta
14 Sep - 06 Oct	Delta
24 Sep - 09 Oct	Delta
12 Sep - 14 Oct	LATAM Airlines Group
30 Sep - 10 Oct	Delta
23 Sep - 12 Oct	easyJet
17 Sep - 05 Oct	Air France
21 Sep - 10 Oct	LATAM Airlines Group
15 Sep - 03 Oct	Ryanair

Also check the deals for one-way flights from Frankfurt to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Santiago in September from $933

Return flights