AirHint found the following cheapest return flights from Guadalajara (GDL) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

27 Dec - 25 Jan	Aeromexico
10 Dec - 17 Dec	Aeromexico
27 Dec - 27 Jan	Aeromexico
27 Dec - 26 Jan	Aeromexico
29 Dec - 22 Jan	Aeromexico
26 Dec - 15 Jan	Aeromexico
07 Dec - 10 Dec	Volaris
22 Dec - 12 Jan	Aeromexico
26 Dec - 02 Jan	Aeromexico
07 Dec - 13 Dec	Mexicana
08 Dec - 22 Dec	Viva
10 Dec - 22 Dec	Viva
17 Dec - 22 Dec	Viva
19 Dec - 22 Dec	Viva
27 Dec - 03 Jan	Copa
22 Dec - 04 Jan	Aeromexico
08 Dec - 17 Dec	Viva
08 Dec - 10 Dec	Viva

Also check the deals for one-way flights from Guadalajara to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guadalajara to Sao Paulo in December from $580

Return flights