AirHint found the following cheapest return flights from Guadalajara (GDL) to Panama City (PTY) in December 2025 (see full year).

Return flights

03 Dec - 21 Dec	Aeromexico
11 Dec - 21 Dec	Aeromexico
11 Dec - 18 Dec	Aeromexico
12 Dec - 19 Dec	Aeromexico
14 Dec - 21 Dec	Aeromexico
15 Dec - 22 Dec	Aeromexico
17 Dec - 24 Dec	Aeromexico
09 Dec - 14 Dec	Copa	direct
30 Dec - 06 Jan	Aeromexico
03 Dec - 21 Dec	Copa	direct
11 Dec - 21 Dec	Copa	direct
30 Dec - 06 Jan	Copa	direct

Also check the deals for one-way flights from Guadalajara to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Guadalajara to Panama City in December from $385

Return flights