AirHint found the following cheapest return flights from Guadalajara (GDL) to Santiago (SCL) in October 2025 (see full year).

Return flights

03 Oct - 10 Oct	Copa
09 Oct - 16 Oct	Copa
21 Oct - 11 Nov	Copa
22 Oct - 09 Nov	Copa
09 Oct - 23 Oct	Copa
20 Oct - 27 Oct	Viva
29 Oct - 16 Nov	Aeromexico
01 Oct - 28 Oct	Viva
10 Oct - 17 Oct	Volaris
11 Oct - 18 Oct	Viva
09 Oct - 24 Oct	Copa
09 Oct - 25 Oct	Copa

Also check the deals for one-way flights from Guadalajara to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guadalajara to Santiago in October from $571

Return flights