AirHint found the following cheapest return flights from Sao Paulo (GRU) to Madrid (MAD) in September 2025 (see full year).

Return flights

22 Sep - 05 Oct	Air China	direct
23 Sep - 05 Oct	Air China	direct
22 Sep - 06 Oct	Air China	direct
29 Sep - 13 Oct	Air China	direct
29 Sep - 19 Oct	Air China	direct
30 Sep - 13 Oct	Air China	direct
29 Sep - 26 Oct	Air China	direct
29 Sep - 27 Oct	Air China	direct
23 Sep - 28 Sep	Air China	direct
26 Sep - 05 Oct	Air China	direct
26 Sep - 02 Oct	Air China	direct
25 Sep - 30 Sep	TAP
24 Sep - 28 Sep	TAP
25 Sep - 29 Sep	TAP
22 Sep - 29 Sep	TAP
21 Sep - 24 Sep	Avianca
22 Sep - 29 Sep	Air China	direct
20 Sep - 25 Sep	Avianca
21 Sep - 27 Sep	Avianca
10 Sep - 21 Sep	Iberia	direct

Also check the deals for one-way flights from Sao Paulo to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Madrid in September from $691

Return flights