AirHint found the following cheapest return flights from Sao Paulo (GRU) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

01 Dec - 09 Dec	Copa
03 Dec - 10 Dec	Copa
01 Dec - 11 Dec	Copa
11 Dec - 20 Dec	GOL Linhas Aéreas
02 Dec - 07 Dec	GOL Linhas Aéreas
01 Dec - 08 Dec	Avianca
02 Dec - 17 Jan	Copa
31 Dec - 29 Jan	Copa
14 Dec - 27 Dec	Copa
31 Dec - 17 Jan	Copa
16 Dec - 31 Dec	Arajet
16 Dec - 27 Dec	Arajet
21 Dec - 29 Jan	Copa
31 Dec - 18 Jan	Copa
31 Dec - 24 Jan	Copa
13 Dec - 20 Dec	Copa
31 Dec - 08 Jan	Copa
21 Dec - 17 Jan	Copa
31 Dec - 07 Jan	Copa
21 Dec - 24 Jan	Copa

Also check the deals for one-way flights from Sao Paulo to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rio Negro

Cheap car rent in Rio Negro

Cheapest return flights from Sao Paulo to Rio Negro in December from $375

Return flights