AirHint found the following cheapest return flights from Sao Paulo (GRU) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

09 Dec - 30 Dec	Copa
09 Dec - 16 Dec	Copa
09 Dec - 15 Dec	Copa
07 Dec - 15 Dec	Copa
08 Dec - 15 Dec	Copa
10 Dec - 17 Dec	Copa
03 Dec - 10 Dec	GOL Linhas Aéreas
01 Dec - 09 Dec	Copa
05 Dec - 15 Dec	GOL Linhas Aéreas
08 Dec - 12 Dec	GOL Linhas Aéreas
09 Dec - 24 Jan	Copa
12 Dec - 10 Jan	GOL Linhas Aéreas
12 Dec - 11 Jan	GOL Linhas Aéreas
30 Dec - 29 Jan	Avianca
09 Dec - 12 Jan	Copa
09 Dec - 01 Jan	Copa
29 Dec - 14 Jan	LATAM Airlines Group
30 Dec - 10 Jan	GOL Linhas Aéreas
31 Dec - 11 Jan	LATAM Airlines Group
25 Dec - 15 Jan	LATAM Airlines Group

Also check the deals for one-way flights from Sao Paulo to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Rio Negro in December from $302

Return flights