AirHint found the following cheapest return flights from Sao Paulo (GRU) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

01 Dec - 15 Dec	Avianca
01 Dec - 19 Dec	Avianca
16 Dec - 23 Dec	Avianca
01 Dec - 11 Dec	Avianca
02 Dec - 23 Dec	Avianca
03 Dec - 17 Dec	Avianca
16 Dec - 16 Jan	LATAM Airlines Group
14 Dec - 20 Dec	LATAM Airlines Group
14 Dec - 24 Dec	LATAM Airlines Group
30 Dec - 08 Jan	LATAM Airlines Group
31 Dec - 04 Jan	LATAM Airlines Group
28 Dec - 04 Jan	Avianca
26 Dec - 03 Jan	Avianca
27 Dec - 03 Jan	Avianca
27 Dec - 04 Jan	Avianca
26 Dec - 04 Jan	Avianca

Also check the deals for one-way flights from Sao Paulo to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Rio Negro in December from $368

Return flights