AirHint found the following cheapest return flights from Sao Paulo (GRU) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

14 Sep - 26 Sep	Copa
07 Sep - 13 Sep	Copa
07 Sep - 14 Sep	Copa
18 Sep - 28 Sep	Copa
19 Sep - 29 Sep	Copa
05 Sep - 18 Sep	Copa
05 Sep - 07 Sep	Copa
05 Sep - 12 Sep	Copa
11 Sep - 19 Sep	Copa
24 Sep - 29 Sep	Copa
21 Sep - 03 Oct	GOL Linhas Aéreas
29 Sep - 03 Oct	GOL Linhas Aéreas
22 Sep - 02 Oct	GOL Linhas Aéreas
05 Sep - 05 Oct	Copa
24 Sep - 01 Oct	Copa

Also check the deals for one-way flights from Sao Paulo to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rio Negro

Cheap car rent in Rio Negro

Cheapest return flights from Sao Paulo to Rio Negro in September from $375

Return flights