AirHint found the following cheapest return flights from Sao Paulo (GRU) to Prague (PRG) in September 2025 (see full year).

Return flights

23 Sep - 30 Sep	TAP
13 Sep - 24 Sep	Avianca
14 Sep - 24 Sep	Avianca
26 Sep - 12 Oct	TAP
12 Sep - 24 Sep	Avianca
13 Sep - 23 Sep	Avianca
14 Sep - 23 Sep	Avianca
06 Sep - 12 Sep	LATAM Airlines Group
08 Sep - 22 Sep	LATAM Airlines Group
16 Sep - 30 Sep	Iberia
19 Sep - 30 Sep	British Airways
26 Sep - 10 Oct	Air France
19 Sep - 04 Oct	KLM
20 Sep - 04 Oct	KLM

Also check the deals for one-way flights from Sao Paulo to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Prague in September from $848

Return flights