AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in October 2025 (see full year).

Return flights

09 Oct - 16 Oct	Copa	direct
19 Oct - 22 Oct	Copa	direct
19 Oct - 28 Oct	Copa	direct
05 Oct - 09 Oct	Copa	direct
05 Oct - 10 Oct	Copa	direct
05 Oct - 11 Oct	Copa	direct
16 Oct - 26 Oct	Copa	direct
01 Oct - 08 Oct	Copa	direct
02 Oct - 08 Oct	Copa	direct
18 Oct - 25 Oct	Copa	direct
30 Oct - 05 Nov	Copa	direct
25 Oct - 09 Nov	Copa	direct
27 Oct - 01 Nov	Avianca
27 Oct - 01 Nov	Copa	direct
20 Oct - 01 Nov	Copa	direct

Also check the deals for one-way flights from Sao Paulo to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in October from $365

Return flights