AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in November 2025 (see full year).

Return flights

19 Nov - 24 Nov	Avianca
20 Nov - 02 Dec	Avianca
24 Nov - 30 Nov	Copa	direct
19 Nov - 24 Nov	Copa	direct
17 Nov - 24 Nov	Copa	direct
14 Nov - 21 Nov	Copa	direct
18 Nov - 24 Nov	Copa	direct
20 Nov - 02 Dec	Copa	direct
24 Nov - 02 Dec	Copa	direct
25 Nov - 02 Dec	Copa	direct
23 Nov - 03 Dec	Copa	direct
19 Nov - 02 Dec	Copa	direct

Also check the deals for one-way flights from Sao Paulo to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in November from $458

Return flights