AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in December 2025 (see full year).

Return flights

03 Dec - 11 Dec	Copa	direct
09 Dec - 16 Dec	Copa	direct
06 Dec - 14 Dec	Copa	direct
12 Dec - 19 Dec	Copa	direct
12 Dec - 21 Dec	Copa	direct
10 Dec - 24 Dec	Copa	direct
13 Dec - 21 Dec	Copa	direct
31 Dec - 07 Jan	Copa	direct
31 Dec - 08 Jan	Copa	direct
31 Dec - 06 Jan	Copa	direct
13 Dec - 20 Dec	GOL Linhas Aéreas
18 Dec - 25 Dec	GOL Linhas Aéreas
18 Dec - 24 Dec	GOL Linhas Aéreas
24 Dec - 01 Jan	GOL Linhas Aéreas
18 Dec - 01 Jan	GOL Linhas Aéreas
30 Dec - 07 Jan	GOL Linhas Aéreas
29 Dec - 18 Jan	GOL Linhas Aéreas
30 Dec - 08 Jan	GOL Linhas Aéreas
19 Dec - 22 Jan	Copa	direct
28 Dec - 02 Jan	GOL Linhas Aéreas

Also check the deals for one-way flights from Sao Paulo to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in December from $424

Return flights