AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in December 2025 (see full year).

Return flights

04 Dec - 09 Dec	GOL Linhas Aéreas
09 Dec - 13 Dec	GOL Linhas Aéreas
10 Dec - 17 Dec	Copa	direct
06 Dec - 22 Dec	Copa	direct
05 Dec - 10 Dec	Copa	direct
04 Dec - 09 Dec	Copa	direct
05 Dec - 17 Dec	Copa	direct
03 Dec - 05 Dec	Copa	direct
03 Dec - 07 Dec	Copa	direct
05 Dec - 28 Dec	Copa	direct
15 Dec - 13 Jan	Avianca
15 Dec - 13 Jan	Copa	direct
31 Dec - 09 Jan	Avianca
28 Dec - 11 Jan	GOL Linhas Aéreas
17 Dec - 20 Jan	Copa	direct
19 Dec - 22 Jan	Copa	direct
31 Dec - 10 Jan	Avianca
27 Dec - 11 Jan	GOL Linhas Aéreas
27 Dec - 10 Jan	GOL Linhas Aéreas
20 Dec - 12 Jan	GOL Linhas Aéreas

Also check the deals for one-way flights from Sao Paulo to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in December from $478

Return flights