AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in September 2025 (see full year).

Return flights

04 Sep - 22 Sep	Avianca
20 Sep - 30 Sep	Copa	direct
13 Sep - 17 Sep	Copa	direct
01 Sep - 08 Sep	Copa	direct
05 Sep - 12 Sep	Copa	direct
16 Sep - 26 Sep	Copa	direct
16 Sep - 21 Sep	Copa	direct
01 Sep - 05 Sep	Copa	direct
21 Sep - 30 Sep	Copa	direct
27 Sep - 11 Oct	Copa	direct
24 Sep - 01 Oct	Copa	direct
25 Sep - 02 Oct	Copa	direct
29 Sep - 06 Oct	Copa	direct
24 Sep - 06 Oct	Copa	direct
18 Sep - 21 Sep	Avianca

Also check the deals for one-way flights from Sao Paulo to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in September from $458

Return flights