AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in September 2025 (see full year).

Return flights

18 Sep - 22 Sep	Copa	direct
26 Sep - 28 Sep	Copa	direct
21 Sep - 28 Sep	Copa	direct
25 Sep - 28 Sep	Copa	direct
19 Sep - 24 Sep	Copa	direct
11 Sep - 16 Sep	Copa	direct
13 Sep - 17 Sep	Copa	direct
30 Sep - 04 Oct	Copa	direct
27 Sep - 04 Oct	Copa	direct
30 Sep - 09 Oct	Copa	direct
28 Sep - 12 Oct	Copa	direct
30 Sep - 07 Oct	Copa	direct
22 Sep - 26 Sep	Copa	direct
10 Sep - 14 Sep	Copa	direct
24 Sep - 28 Sep	Copa	direct
27 Sep - 05 Oct	Copa	direct
07 Sep - 12 Oct	GOL Linhas Aéreas
07 Sep - 12 Oct	Copa	direct

Also check the deals for one-way flights from Sao Paulo to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in September from $365

Return flights