AirHint found the following cheapest return flights from Guatemala City (GUA) to Madrid (MAD) in September 2025 (see full year).

Return flights

15 Sep - 22 Sep	Spirit Airlines
03 Sep - 17 Sep	Spirit Airlines
12 Sep - 29 Sep	Avianca
17 Sep - 24 Sep	Avianca
06 Sep - 07 Oct	Spirit Airlines
17 Sep - 22 Sep	Avianca
14 Sep - 28 Sep	Volaris El Salvador
22 Sep - 30 Sep	United
25 Sep - 07 Oct	jetBlue
20 Sep - 27 Sep	United
26 Sep - 06 Oct	jetBlue
26 Sep - 16 Oct	United
27 Sep - 14 Oct	United
16 Sep - 15 Oct	United
14 Sep - 02 Oct	United
20 Sep - 29 Sep	United
14 Sep - 21 Sep	United
17 Sep - 02 Oct	United
26 Sep - 05 Oct	Avianca
29 Sep - 17 Oct	United

Also check the deals for one-way flights from Guatemala City to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Madrid in September from $711

Return flights