AirHint found the following cheapest return flights from Guatemala City (GUA) to Madrid (MAD) in September 2025 (see full year).

Return flights

15 Sep - 30 Sep	Spirit Airlines
17 Sep - 30 Sep	Spirit Airlines
14 Sep - 29 Sep	Spirit Airlines
16 Sep - 24 Sep	Spirit Airlines
10 Sep - 21 Sep	Spirit Airlines
08 Sep - 14 Sep	Spirit Airlines
08 Sep - 15 Sep	Spirit Airlines
14 Sep - 23 Sep	Spirit Airlines
28 Sep - 14 Oct	Spirit Airlines
24 Sep - 14 Oct	Avianca
13 Sep - 29 Sep	Spirit Airlines
11 Sep - 16 Sep	Spirit Airlines
29 Sep - 15 Oct	Spirit Airlines
24 Sep - 06 Oct	jetBlue
13 Sep - 04 Oct	Spirit Airlines
17 Sep - 04 Oct	Spirit Airlines
22 Sep - 13 Oct	United
25 Sep - 09 Oct	United
11 Sep - 09 Oct	United
22 Sep - 09 Oct	United

Also check the deals for one-way flights from Guatemala City to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Madrid in September from $613

Return flights