AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in October 2025 (see full year).

Return flights

03 Oct - 07 Oct	Copa
06 Oct - 13 Oct	Copa
03 Oct - 05 Oct	Copa
02 Oct - 04 Oct	Copa	direct
02 Oct - 05 Oct	Copa	direct
15 Oct - 19 Oct	Copa	direct
12 Oct - 21 Oct	Copa	direct
13 Oct - 19 Oct	Copa	direct
23 Oct - 27 Oct	Copa	direct
21 Oct - 25 Oct	Copa	direct
31 Oct - 02 Nov	Copa	direct
24 Oct - 03 Nov	Copa	direct
29 Oct - 05 Nov	Copa	direct
31 Oct - 03 Nov	Copa	direct
06 Oct - 03 Nov	Copa	direct
26 Oct - 01 Nov	Copa

Also check the deals for one-way flights from Guatemala City to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in October from $248

Return flights