AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in October 2025 (see full year).

Return flights

06 Oct - 11 Oct	Avianca
06 Oct - 15 Oct	Avianca
18 Oct - 21 Oct	Avianca
13 Oct - 17 Oct	Avianca
02 Oct - 04 Oct	Avianca
01 Oct - 04 Oct	Avianca
02 Oct - 05 Oct	Avianca
24 Oct - 26 Oct	Avianca
24 Oct - 03 Nov	Avianca
27 Oct - 29 Oct	Avianca
30 Oct - 06 Nov	Avianca
26 Oct - 04 Nov	Avianca
21 Oct - 23 Oct	Avianca
29 Oct - 02 Nov	Copa	direct
26 Oct - 04 Nov	Copa	direct
31 Oct - 05 Nov	Copa	direct
31 Oct - 04 Nov	Copa	direct
24 Oct - 03 Nov	Copa	direct
30 Oct - 06 Nov	Copa	direct

Also check the deals for one-way flights from Guatemala City to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in October from $179

Return flights