AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in December 2025 (see full year).

Return flights

09 Dec - 13 Dec	Avianca
11 Dec - 15 Dec	Avianca
21 Dec - 26 Dec	Avianca
05 Dec - 08 Dec	Avianca
22 Dec - 28 Dec	Copa	direct
22 Dec - 24 Dec	Copa	direct
05 Dec - 12 Dec	Copa	direct
21 Dec - 26 Dec	Copa	direct
25 Dec - 29 Dec	Copa	direct
25 Dec - 30 Dec	Copa	direct
30 Dec - 02 Jan	Copa	direct
30 Dec - 05 Jan	Copa	direct
25 Dec - 07 Jan	Copa	direct
28 Dec - 01 Jan	Copa	direct
28 Dec - 02 Jan	Copa	direct
14 Dec - 03 Jan	Copa	direct
30 Dec - 03 Jan	Copa	direct
28 Dec - 25 Jan	Copa	direct
26 Dec - 27 Jan	Copa
29 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Guatemala City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in December from $257

Return flights