AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in September 2025 (see full year).

Return flights

19 Sep - 26 Sep	Avianca
30 Sep - 02 Oct	Avianca
29 Sep - 03 Oct	Avianca
17 Sep - 22 Sep	Avianca
30 Sep - 04 Oct	Avianca
20 Sep - 27 Sep	Avianca
30 Sep - 05 Oct	Avianca
19 Sep - 28 Sep	Avianca
28 Sep - 29 Sep	Avianca
21 Sep - 22 Sep	Avianca
17 Sep - 26 Sep	Avianca
24 Sep - 27 Sep	Copa	direct
24 Sep - 28 Sep	Copa	direct
25 Sep - 29 Sep	Copa	direct
30 Sep - 02 Oct	Copa	direct
30 Sep - 04 Oct	Copa	direct
29 Sep - 03 Oct	Copa	direct
30 Sep - 05 Oct	Copa	direct
20 Sep - 04 Oct	Copa

Also check the deals for one-way flights from Guatemala City to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in September from $179

Return flights