AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in September 2025 (see full year).

Return flights

25 Sep - 30 Sep	Copa
20 Sep - 27 Sep	Copa
24 Sep - 27 Sep	Copa
23 Sep - 24 Sep	Copa
28 Sep - 01 Oct	Copa
29 Sep - 06 Oct	Copa
20 Sep - 23 Sep	Copa
30 Sep - 03 Oct	Copa	direct
29 Sep - 06 Oct	Copa	direct
26 Sep - 29 Sep	Copa	direct
25 Sep - 30 Sep	Copa	direct
25 Sep - 26 Sep	Copa	direct
26 Sep - 30 Sep	Copa	direct
30 Sep - 07 Oct	Copa	direct
23 Sep - 24 Sep	Copa	direct

Also check the deals for one-way flights from Guatemala City to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in September from $207

Return flights