AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in September 2025 (see full year).

Return flights

14 Sep - 18 Sep	Avianca
05 Sep - 07 Sep	Avianca
14 Sep - 21 Sep	Avianca
14 Sep - 17 Sep	Avianca
27 Sep - 05 Oct	Avianca
01 Sep - 10 Oct	Avianca
12 Sep - 15 Sep	Avianca
07 Sep - 10 Sep	Avianca
16 Sep - 23 Sep	Avianca
07 Sep - 09 Sep	Avianca
19 Sep - 29 Sep	Avianca
05 Sep - 09 Sep	Avianca
01 Sep - 10 Oct	Copa	direct

Also check the deals for one-way flights from Guatemala City to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in September from 252€

Return flights