AirHint found the following cheapest return flights from Guatemala City (GUA) to Santo Domingo (SDQ) in September 2025 (see full year).

Return flights

29 Sep - 04 Oct	Arajet	direct
22 Sep - 30 Sep	Arajet	direct
25 Sep - 29 Sep	Copa
27 Sep - 29 Sep	Copa
24 Sep - 29 Sep	Copa
18 Sep - 18 Oct	Arajet	direct
20 Sep - 27 Sep	Avianca
20 Sep - 27 Sep	Arajet	direct
22 Sep - 27 Sep	Arajet	direct
27 Sep - 29 Sep	Arajet	direct
25 Sep - 29 Sep	Arajet	direct
18 Sep - 26 Sep	Copa

Also check the deals for one-way flights from Guatemala City to Santo Domingo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Santo Domingo in September from $288

Return flights