AirHint found the following cheapest return flights from Guayaquil (GYE) to Madrid (MAD) in October 2025 (see full year).

Return flights

24 Oct - 09 Nov	Air Europa	direct
26 Oct - 13 Nov	Avianca
23 Oct - 14 Nov	Avianca
26 Oct - 17 Nov	Avianca
19 Oct - 22 Oct	Air Europa	direct
24 Oct - 07 Nov	Air Europa	direct
26 Oct - 09 Nov	Air Europa	direct
29 Oct - 16 Nov	Air Europa	direct
22 Oct - 21 Nov	Air Europa	direct
12 Oct - 12 Nov	Avianca
29 Oct - 10 Nov	Iberia
02 Oct - 23 Oct	jetBlue
12 Oct - 22 Oct	jetBlue
06 Oct - 26 Oct	jetBlue
06 Oct - 14 Oct	jetBlue
12 Oct - 26 Oct	jetBlue
17 Oct - 27 Oct	jetBlue
19 Oct - 26 Oct	Avianca
19 Oct - 27 Oct	jetBlue
04 Oct - 13 Oct	jetBlue

Also check the deals for one-way flights from Guayaquil to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Madrid in October from $794

Return flights