AirHint found the following cheapest return flights from Guayaquil (GYE) to Madrid (MAD) in September 2025 (see full year).

Return flights

22 Sep - 30 Sep	Avianca
21 Sep - 30 Sep	Avianca
20 Sep - 30 Sep	Avianca
29 Sep - 06 Oct	jetBlue
28 Sep - 22 Oct	Avianca
10 Sep - 30 Sep	Avianca
11 Sep - 25 Sep	Avianca
20 Sep - 23 Sep	Avianca
14 Sep - 21 Sep	Avianca
11 Sep - 21 Sep	Avianca
10 Sep - 20 Sep	Avianca
10 Sep - 25 Sep	Avianca
27 Sep - 28 Oct	Avianca
29 Sep - 12 Oct	jetBlue
27 Sep - 07 Oct	Copa
29 Sep - 29 Oct	Avianca
22 Sep - 22 Oct	Avianca
27 Sep - 08 Oct	Avianca
27 Sep - 04 Oct	Copa
20 Sep - 04 Oct	Avianca

Also check the deals for one-way flights from Guayaquil to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid

Cheapest return flights from Guayaquil to Madrid in September from $889

Return flights