AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

18 Oct - 23 Oct	Copa
23 Oct - 27 Oct	Copa
10 Oct - 13 Oct	Avianca	direct
08 Oct - 15 Oct	Copa
09 Oct - 12 Oct	Avianca
24 Oct - 27 Oct	Copa
01 Oct - 04 Oct	Copa
08 Oct - 13 Oct	Avianca	direct
03 Oct - 06 Oct	Avianca	direct
31 Oct - 07 Nov	Avianca	direct
24 Oct - 27 Oct	Avianca	direct
28 Oct - 03 Nov	Copa
31 Oct - 05 Nov	Avianca
31 Oct - 04 Nov	Avianca
30 Oct - 03 Nov	Copa
30 Oct - 04 Nov	Copa
09 Oct - 04 Nov	Copa
31 Oct - 03 Nov	Avianca

Also check the deals for one-way flights from Guayaquil to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in October from $263

Return flights