AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

11 Oct - 14 Oct	Copa
13 Oct - 17 Oct	Avianca	direct
22 Oct - 29 Oct	Avianca	direct
09 Oct - 15 Oct	Copa
17 Oct - 24 Oct	Copa
03 Oct - 08 Oct	Copa
31 Oct - 07 Nov	Copa
29 Oct - 02 Nov	Avianca
27 Oct - 02 Nov	Avianca
17 Oct - 20 Oct	Avianca
10 Oct - 13 Oct	Avianca
10 Oct - 14 Oct	Avianca
09 Oct - 14 Oct	Copa
30 Oct - 02 Nov	Avianca
29 Oct - 03 Nov	Copa
29 Oct - 03 Nov	Avianca	direct
31 Oct - 05 Nov	Avianca
31 Oct - 05 Nov	Avianca	direct
31 Oct - 03 Nov	Avianca	direct
31 Oct - 04 Nov	Copa

Also check the deals for one-way flights from Guayaquil to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in October from $288

Return flights